| Pair Name | Luteolin, Tamoxifen | ||
| Phytochemical Name | Luteolin (PubChem CID: 5280445 ) | ||
| Anticancer drug Name | Tamoxifen (PubChem CID: 2733526 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Luteolin, Tamoxifen | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Gene Regulation | Down-regulation | Expression | CCNE2 | hsa9134 |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| BT-483 | Invasive breast carcinoma | Homo sapiens (Human) | CVCL_2319 | |
| BT-474 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0179 | |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 | |
| AU565 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_1074 | |
| MCF-10A | Healthy | Homo sapiens (Human) | CVCL_0598 | |
| Result | The results of this study suggest that luteolin can be used as a chemosensitiser to target the expression level of CCNE2 and that it could be a novel strategy to overcome TAM resistance in breast cancer patients. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Luteolin sensitises drug-resistant human breast cancer cells to tamoxifen via the inhibition of cyclin E2 expression. Food Chem. 2013 Nov 15;141(2):1553-61. doi: 10.1016/j.foodchem.2013.04.077. | Click |
